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DFG Research Unit 1334


Prof. Dr. Reinhard Fischer

Phone:  +49 721 608-44630

Secret.: +49 721 608-44632

Fax:      +49 721 608-44509


reinhard fischerPcq9∂kit edu

Dr. Meritxell Riquelme

Phone:  +52 646 175-0500 ext. 27061   

Fax:      +52 646 175-0595 ext. 27052


riquelmeXkg8∂cicese mx


Pohlmann, T., Baumann, S., Haag, C., Albrecht, M. & Feldbrügge, M. (2015) A FYVE zinc finger domain protein specifically links mRNA transport to endosome trafficking. eLife, in press.


Fajardo-Somera, R.A., Jöhnk, B., Roberson, R.W., Bayram, Ö., Valerius, O., Braus, G.H. & Riquelme, M. (2015) Dissecting the function of different chitin synthases in vegetative growth and sexual development in Neurospora crassa. Fung. Genet. Biol., 75:30-45.


Sánchez-León, E., Bowman, B., Seidel, C., Fischer, R., Novick, P. & Riquelme, M. (2015) The Rab GTPase YPT-1 associates with Golgi cistern and Spitzenkörper micro vesicles in Neurospora crassaMol. Microbiol., 95:472-490.


Baumann, S., Grün, N., Takeshita, N., Fischer, R. and Feldbrügge, M. (2015). Live cell imaging of endosomal trafficking in fungi. in Meth. Mol. Biol., Membrane Trafficking: 2nd edition, ed. Bor Luen Tang, Springer Science & Business Media New York, 1270:347-363.


Pöhlmann, J., Risse, C., Seidel, C., Pohlmann, T., Jakopec, V., Walla, E., Ramrath, P., Takeshita, N., Feldbrügge, M., Fischer, R. & Fleig, U. (2014). The Vip1 inositol polyphosphate kinase family regulates polarized growth and modulates the microtubule cytoskeleton in fungi. PLoS Genet., 10(9):e1004586.


Herrero de Vega, S., Takeshita, N. & Fischer, R. (2014) The F-box protein RcyA controls the turnover of the kinesin-7 motor KipA in Aspergillus nidulans. Eukaryot. Cell, 13:1085-1094.


Takeshita, N., Manck, R., Grün, N., Herrero de Vega, S. & Fischer, R. (2014) Interdependence of the actin and the microtubule cytoskeleton during fungal growth. Curr. Opin. Microbiol., 20:34-41.


Dirschnabel, D. E., Nowrousian, M., Cano-Domínguez, N. Aguirre, J., Teichert, I. and Kück, U. (2014). New insights into the roles of NADPH oxidases in sexual development and ascospore germination in Sordaria macrospora. Genetics. 196: 729-744.


Baumann, S., König, J., Koepke, J. and Feldbrügge, M. (2014). Endosomal transport of septin mRNA and protein indicates local translation on endosomes and is required for correct septin filamentation. EMBO Rep. 15:94-102.


Riquelme, M., Bredeweg, E. L., Callejas-Negrete, O., Ludwig, S., Roberson, R. W., Seiler, S., Beltrán-Aguilar, A., Novick, P., & Freitag, M. (2014). The Neurospora crassa exocyst complex tethers Spitzenkörper vesicles to the apical plasma membrane during polarized growth. Mol Biol Cell. 25: 1312-1326.


Terfrüchte, M., Jöhnk, B., Fajardo-Somera, R., Braus, G. H., Riquelme, M., Schipper, K., and Feldbrügge. M. (2014). Establishing a versatile Golden Gate cloning system for genetic engineering in fungi. Fungal Genet. & Biol. 62: 1-10.


Jansen, R.-P., Niessing, D., Baumann, S., and Feldbrügge, M. (2014). mRNA transport meets membrane traffic. Trends in Genet. 30: 408-417.


Riquelme, M., & Sánchez-León, E.. (2014). The Spitzenkörper: a choreographer of fungal growth and morphogenesis. Curr Opin. Microbiol 20: 27-33.


Riquelme, M. (2013). Tip growth in filamentous fungi: a road trip to the apex. Ann Rev Microbiol 67: 587-609.


Seidel, C., Moreno-Velásquez, S. D., Riquelme, M., and Fischer, R. (2013). Neurospora crassa NKIN2, a kinesin-3 motor, transports early endosomes and is required for polarized growth. Eukaryot. Cell. 12: 1020-1032.


Mouriño-Pérez, R. R., and Riquelme, M. (2013). Recent advances in septum biogenesis in Neurospora crassa. In: Advances in Genetics. T. Friedmann, J. C. Dunlap and S. F. Goodwin (Eds.). Vol. 83; Ch. 3; p. 99-134. ISBN: 978-0-12-407675-4. Elsevier.


Heimel, K., Freitag, J., Hampel, M., Ast, J., Bölker, M., and Kämper, J. (2013). Crosstalk between the unfolded protein response and pathways that regulate pathogenic development in Ustilago maydis. Plant Cell. 25: 4262-4277.


Takeshita, N., Mania, D., Herrero de Vega, S., Ishitsuka, Y., Nienhaus, G.U., Podolski, M., Howard, J. & Fischer, R. (2013). The cell end marker TeaA and the microtubule polymerase AlpA contribute to mirotubule guidance at the hyphal tip cortex of Aspergillus nidulans for polarity maintenance. J Cell Sci, 126:5400-5411.  


Göhre, V., Vollmeister, E., Bölker, M., and Feldbrugge, M. (2012). Microtubule-dependent membrane dynamics in Ustilago maydis: Trafficking and function of Rab5a-positive endosomes. Commun. Integr. Biol. 5: 485-490.


Seidel, C., Zekert, N. & Fischer, R. (2012). The Aspergillus nidulans kinesin-3 tail is necessary and sufficient to recognize modified microtubules. PLoS One 7, e30976.



Baumann, S., Pohlmann, T., Jungbluth, M., Brachmann, A. & Feldbrügge M. (2012) Kinesin-3 and dynein mediate microtubule-dependent co-transport of mRNPs and endosomes. J. Cell Sci. 125: 2740-2752.



Vollmeister, E., Schipper, K. & Feldbrügge M. (2012) Microtubule-dependent mRNA transport in the model microorganism Ustilago maydis. RNA Biol. 9: 1-8.



Vollmeister, E., Schipper, K., Baumann, S., Haag, C., Pohlmann, T., Stock J. & Feldbrügge M. (2012) Fungal development of the plant pathogen Ustilago maydis. FEMS Microbio. Rev. 36: 59-77.


Richthammer, C., Enseleit, M., Sanchez-Leon, E., März, S.,, Heilig, Y., Riquelme, M., & Seiler, S. (2012). RHO1 and RHO2 share partially overlapping functions in the regulation of cell wall integrity and hyphal polarity in Neurospora crassa. Mol. Microbiol. 85:  716–733.



Echauri-Espinosa, R.O., Callejas-Negrete, O.A., Roberson, R.W., Bartnicki-García, S. & Mouriño-Pérez, R.R. (2012) Coronin Is a Component of the Endocytic Collar of Hyphae of Neurospora crassa and Is Necessary for Normal Growth and Morphogenesis. PLoS ONE 7(5): e38237. doi:10.1371/journal.pone.0038237.


Vollmeister, E., Schipper, K., Baumann, S., Haag, C., Pohlmann, T., Stock, J. and Feldbrügge M. (2012) Fungal development of the plant pathogen Ustilago maydis. FEMS Microbio Rev. 36: 59-77


Baumann, S., Pohlmann, T., Jungbluth, M., Brachmann, A. and Feldbrügge M. (2012) Kinesin-3 and dynein mediate microtubule-dependent co-transport of mRNPs and endosomes. J. Cell Sci. 125: 2740-2752.



Takeshita, N., Diallinas, G. & Fischer, R. (2012). The role of flotillin FloA and stomatin StoA in the maintenance of apical sterol-rich membrane domains and polarity in the filamentous fungus Aspergillus nidulans. Mol Microbiol 83, 1136-1152.


Nowrousian M, Teichert I, Masloff S, Kück U (2012) Whole-genome sequencing of Sordaria macrospora mutants identifies developmental genes. G3 (Bethesda) 2: 261-270.


Arratia-Quijada, J., Sánchez, O., Scazzocchio, C. & Aguirre, J. (2012). FlbD, a Myb Transcription Factor of Aspergillus nidulans is uniquely involved in both Asexual and Sexual Differentiation. Eukaryot Cell. 11(9): 1132-1142.


Huber EM, Scharf DH, Hortschansky P, Groll M, Brakhage AA (2012) DNA Minor Groove Sensing and Widening by the CCAAT-Binding Complex. Structure, in press.



Bloemendal S, Bernhards Y, Bartho K, Dettmann A, Voigt O, Teichert I, Seiler S, Wolters DA, Pöggeler S, Kück U (2012) A homolog of the human STRIPAK complex controls sexual development in fungi. Mol Microbiol 84: 310-323.


Hansberg, W., Salas-Lizana, R. & Domínguez, L. (2012). Fungal catalases: Function, phylogenetic origin and structure. Arch Biochem Biophys 525, 170-180.



von Zeska Kress, M.R., Harting, R., Bayram, Ö., Christmann, M., Irmer, H., Valerius, O., Schinke, J., Goldman, G.H. & Braus, G.H. (2012). The COP9 signalosome counteracts the accumulation of cullin SCF ubiquitin E3 RING ligases during fungal development. Mol Microbiol 83, 1162-1177.



Gerke, J., Bayram, Ö. & Braus, G.H. (2012). Fungal S-adenosylmethionine synthetase and the control of development and secondary metabolism in Aspergillus nidulansFungal Genet Biol doi:10.1016/j.fgb.2012.04.003.



Bayram, Ö., Bayram, Ö.S., Ahmed, Y.L., Maruyama, J., Valerius, O., Rizzoli, S.O., Ficner, R., Irniger, S. & Braus, G.H. (2012). The Aspergillus nidulans MAPK module AnSte11-Ste50-Ste7-Fus3 controls development and secondary metabolism. PLoS Genet 8: e1002816. doi:10.1371/journal.pgen.1002816.g009.



Teichert I, Wolff G, Kück U*, Nowrousian M* (2012) Combining laser microdissection and RNA-seq to chart the transcriptional landscape of fungal development. BMC Genomics (* corresponding authors) (in press)


Highlighted here: http://aktuell.ruhr-uni-bochum.de/pm2012/pm00321.html.en



Carreras-Villaseñor N., Sánchez-Arreguín A., and Herrera-Estrella A. (2012)Trichoderma sensing the environment for survival and dispersal. Microbiology 153: 3-16.



Hernández-Oñate, M.A., Esquivel-Naranjo, E.U., Mendoza-Mendoza, A., Stewart, A. & Herrera-Estrella, A. (2012). An injury response mechanism conserved across kingdoms determines entry into development in the fungus Trichoderma atrovirideProc. Natl. Acad. Sci. USA 109: 14918-14923.



Herrero, S., Takeshita, N. & Fischer, R. (2011). The Aspergillus nidulans CENP-E kinesin motor KipA interacts with the fungal homologue of the centromere-associated protein CENP-H at the kinetochore. Mol Microbiol 80, 981-994.


Koepke, J., Kaffarnik, F., Haag, C., Zarnack, K., Luscombe, N.M., König, J., Ule, J., Kellner, R., Begerow D. & Feldbrügge M. (2011) The RNA-binding protein Rrm4 is essential for efficient secretion of endochitinase Cts1. Mol. Cell. Proteom. M111.011213: 1-15.



Takeshita, N. & Fischer, R. (2011). On the Role of microtubules, cell end markers, and septal microtubule organizing centers on site selection for polar growth in Aspergillus nidulans. Fungal Biol 115, 506-517.


Sánchez-León, E., Verdín, J., Freitag, M., Roberson, R.W., Bartnicki-García, S. & Riquelme, M. (2011). Traffic of chitin synthase 1 (CHS-1) to the Spitzenkörper and developing septa in hyphae of Neurospora crassa: actin dependence and evidence of distinct microvesicle populations. Eukaryot. Cell. 10: 683-695.



Frieser S.H., Hlubek A., Sandrock,B. & Bölker M. (2011). Cla4 kinase triggers destruction of the Rac1-GEF Cdc24 during polarized growth in Ustilago maydis. Mol Biol Cell  22:3253-3262.


Freitag J., Lanver D., Böhmer C., Schink K.O., Bölker M. & Sandrock B. (2011). Septation of infectious hyphae is critical for appressoria formation and virulence in the smut fungus Ustilago maydis. PLoS Pathog. 7, e1002044.



Böhmer M., Bölker M. & Romeis, T. (2011) Chemical genetic analysis of protein kinase function in plants. Methods Mol. Biol. 779:259-271.


Schunck, T., Herrero de Vega, S. & Fischer, R. (2011) The Aspergillus nidulans CENP-E kinesin KipA is able to form a dimer and move processively along microtubules. Curr. Genet., 57:335-341.


Lara-Rojas, F., Sánchez, O. Kawasaki, L. & Aguirre, J. (2011)Aspergillus nidulans Transcription factor AtfA interacts with the MAPK SakA to Regulate General Stress Responses, Development and Spore Functions. Mol. Microbiol. 80(2): 436-454.


Takeshita, N. & Fischer, R. (2011) On the role of microtubules, cell end markers, and septal microtubule organizing centers on site selection for polar growth in Aspergillus nidulansFungal Biol., 115:506-517.


Nützmann HW, Reyes-Dominguez Y, Scherlach K, Schroeckh V, Horn F, Gacek A, Schümann J, Hertweck C, Strauss J, Brakhage AA (2011) Bacteria-induced natural product formation in the fungus Aspergillus nidulans requires Saga/Ada-mediated histone acetylation. Proc Natl Acad Sci USA 108, 14282-14287.


Herrero de Vega, S., Takeshita, N. & Fischer, R. (2011). The Aspergillus nidulans CENP-E kinesin motor KipA interacts with the fungal homolog of the centromere-associated protein H at the kinetochore. Mol. Microbiol., 80(4):981-994.  


Helmstaedt K., Schwier E.U., Christmann M., Nahlik K., Westermann M., Harting R., Grond S., Busch S., Braus G.H. (2011) Recruitment of the inhibitor Cand1 to the cullin substrate adaptor site mediates interaction to the neddylaton site. Mol Biol Cell. 22, 153-164.



Nahlik K., Dumkow M., Bayram Ö., Helmstaedt K., Busch S., Valerius O., Gerke J., Hoppert M., Schwier E., Opitz L., Westermann M., Grond S., Feussner K., Goebel C., Kaever A., Meinecke P., Feussner I., Braus G.H. (2010) The COP9 signalosomemediates transcriptional and metabolic response to hormones, oxidative stress protection and cell wall rearrangement during fungal development. Mol. Microb. 78, 962-979.



Sarikaya Bayram Ö., Bayram Ö., Valerius O., Park H.S., Irniger S., Gerke J., Ni M., Han K.H., Yu J.H. & Braus G.H. (2010) LaeA control of velvet family regulatory proteins for light-dependent development and fungal cell-type specificity. PLoS Genet. 6,  e1001226



Heimel, K., Scherer, M., Schuler, D. & Kämper, J. (2010). The Ustilago maydis Clp1 protein orchestrates pheromone and b-dependent signaling pathways to coordinate the cell cycle and pathogenic development. Plant Cell 22, 2908-2922.


Zekert, N., Veith, D. & Fischer, R. (2010). Interaction of the Aspergillus nidulans mircrotubule-organizing center (MTOC) component ApsB with gamma-tubulin and evidence for a role of a subclass of peroxisomes in the formation of septal MTOCs. Eukaryot Cell 9, 795-805.



Heimel, K., Scherer, M., Vranes, M., Wahl, R., Pothiratana, C., Schuler, D., Vincon, V., Finkernagel, V., Flor-Parra, I., & Kämper, J. (2010). The transcription factor Rbf1 is the master regulator for b-mating type controlled pathogenic development in Ustilago maydis. PLoS Pathogens 6, e1001035.


Nowrousian M, Stajich JE, Chu M, Engh I, Espagne E, Halliday K, Kamerewerd J, Kempken F, Knab B, Kuo HC, Osiewacz HDPöggeler S, Read ND, Seiler S,  Smith KM, Zickler D, Kück U, Freitag M (2010). De novo assembly of a 40 Mb eukaryotic genome from short sequence reads: Sordaria macrospora, a model organism for fungal morphogenesis. PLoS Genetics 6(4): e1000891.


Bathe, F., Kempf, C., Osmani, A., Osmani, A. H., Hettinger, S., Wohlmann, E. & Fischer, R. (2010). Functional characterization of a new member of the Cdk9 family in Aspergillus nidulansEukaryot Cell 9, 1901-1912.



Delgado-Álvarez, D. L., Callejas-Negrete, O. A., Gómez, N., Freitag, M., Roberson, R. W., Smith, L. G. & Mouriño-Pérez, R. R. (2010). Vizualization of F-actin localization and dynamics with live cell markers in Neurospora crassa. Fungal Genet. Biol47: 573-586.



Pöhlmann, J. & Fleig, U. (2010) Asp1, a conserved 1/3 inositol polyphosphate kinase, regulates the dimorphic switch in Schizosaccharomyces pombe. Mol Cell Biol. 30: 4537. 4535-4547.



Zarnack, K. & Feldbrügge M. (2010) Microtubule-dependent mRNA transport in fungi. Euk. Cell 9: 982-990.


Roberson, R.W., Abril, M., Blackwell, M., Letcher, P., McLaughlin, D.J., Mouriño-Pérez, R.R., Riquelme, M. & Uchida, M. (2010). Hyphal structure. In: Cellular and Molecular Biology of Filamentous Fungi. K. Borkovich and D. Ebbole (Eds.). p. 8-24. ASM Press.


Bloemendal S, Lord KM, Rech C, Hoff B, Engh I, Read ND, Kück U (2010). A mutant defective in sexual development produces aseptate ascogonia. Eukaryot Cell 9: 1856–1866.



Engh I, Nowrousian M, Kück U (2010) Sordaria macrospora, a model organism to study fungal cellular development. Eur J Cell Biol 89: 864–872.


Vollmeister, E. & Feldbrügge M. (2010) Posttranscriptional control of growth and development in Ustilago maydis. Curr. Op. Microbio. 13: 693-699.



Wahl, R., Zahiri, A. & Kämper, J. (2010). The Ustilago maydis b mating type locus controls hyphal proliferation and expression of secreted virulence factors in planta. Mol Microbiol 75, 208-220.



Zahiri, A., Heimel, K., Wahl, R., Rath, M. & Kämper, J. (2010). The Ustilago maydis forkhead transcription factor Fox1 is involved in the regulation of genes required for the attenuation of plant defenses during pathogenic development. Mol Plant Mic Int: 23, 1118-1129.



Domínguez, L., Sosa-Peinado, A. & Hansberg, W. (2010). Catalase evolved to concentrate H2O2 at its active site. Arch Biochem Biophys 500, 82-91.